Resolve
Say ‘Good-Bye’ to Inflammation
WHAT IT IS:
- A concentrated marine lipid formula enriched in Specialized Pro-Resolving Mediators (SPMs) – the signaling molecules that actively switch inflammation off
WHY YOU NEED IT:
- Important for patients with acute and chronic inflammation
- Targets patients struggling with inflammation that is unresponsive to traditional anti-inflammatories
- Good for patients with arthritis, back pain, neck pain, irritated skin, sports injuries, post viral fatigue, Long Covid, CIRS, and muscle aches
HOW IT HELPS:
For decades, inflammation was understood as something that simply faded once the trigger was removed. That view turned out to be wrong. Resolution is an active, tightly orchestrated program driven by a distinct family of signaling molecules – resolvins, protectins, maresins and lipoxins, known collectively as specialized pro-resolving mediators. When that program runs properly, inflammation completes its job and shuts down. When it fails, inflammation persists at a low grade indefinitely, which is the pattern underlying a great many chronic conditions.
SPMs are manufactured from the omega-3 fatty acids EPA and DHA. Standard fish oil supplies these precursors and assumes the body will handle the rest. In practice the enzymatic conversion is inefficient, and it becomes measurably less efficient with age, obesity, insulin resistance and chronic inflammatory disease – precisely the patients who most need resolution to work.
Resolve works differently from anti-inflammatory drugs. Rather than blocking the production of inflammatory signals, SPMs work on the resolution end – counter-regulating pro-inflammatory mediators, enhancing the ability of immune cells to clear cellular debris and spent immune cells, promoting clearance of microbes, modulating pain-signaling channels, and supporting tissue repair. The distinction matters: suppression halts a process, while resolution completes it.
The clinical work is impressive. A randomized, double-blind, placebo-controlled trial in adults with symptomatic knee osteoarthritis evaluated SPM-enriched oil for pain, function and quality of life. A clinical study in patients with persistent post-COVID symptoms documented significant increases in circulating 17-HDHA, 18-HEPE and 14-HDHA and a favorable shift in the ratio of pro-inflammatory to pro-resolving lipid mediators, alongside a trend toward improved fatigue and breathlessness.
Dosage:
Take one to two softgels daily with a meal. During periods of increased need, Dr. Hirt may direct a higher short-term dose.
Cautions:
Contains fish (anchovy, sardine, herring and mackerel) and squid. Do not use if you have a fish or shellfish allergy.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The Center for Integrative Medicine • Michael Hirt, M.D. • 5620 Wilbur Avenue, Suite 220, Tarzana, CA 91356 • 818.345.2828